H2N2V1, Main, Exploration, bibRecord, 002A74

Correlation between base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses

Identifieur interne : 002A74 ( Main/Exploration ); précédent : 002A73; suivant : 002A75

Correlation between base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses

Auteurs : C. Scholtissek [Allemagne] ; W. Rohde [Allemagne] ; E. Harms [Allemagne] ; R. Rott [Allemagne]

Source :

Virology [ 0042-6822 ] ; 1977.

RBID : ISTEX:EAC6E1AC77A96B929F10BDF0417D62678201D54E

English descriptors

Teeft :
- Academic press, Antigenic, Antigenic shift, Antigenically, Base sequence homology, Crna, Equine, Fowl plague virus, Gene coding, Hemagglutination inhibition test, Hemagglutinin, Hemagglutinin gene, Hemagglutinins, Heterologous hybrids, Homology, Hong kong, Hong kong strain, Hybrid, Hybridization, Influenza, Influenza strains, Influenza viruses, Input radioactivity, Point mutations, Prototype strains, Recombination, Rnase, Rohde, Scholtissek, Segment, Sequence homology, Serological relationship, Swine, Various influenza.

Abstract

Abstract: Base sequence homology between PR8 segment 4, the gene coding for the hemagglutinin, and the cRNAs of other influenza A prototype strains was determined. One hundred percent base sequence homology was found between PR8 (HO) and FMl (Hl), and 80% homology between PR8 and swine influenza virus (HSW1), although there is no cross-inhibition of hemagglutination. This is in clear contrast to other antigenically unrelated strains, which exhibit a base sequence homology between 20 and 40% with regard to segment 4. Fowl plague virus (FPV) and the Dutch strain, and equine 2 virus and the Hong Kong strain, which have antigenically related hemagglutinins, exhibit a base sequence homology of 100 and 80%, respectively. The available data suggest that swine, PR8, and FMl comprise one “subtype” genetically and are not derived by recombination, but differ by a number of point mutations.

Url:

https://api.istex.fr/ark:/67375/6H6-6H3GMZ85-Z/fulltext.pdf

DOI: 10.1016/0042-6822(77)90360-9

Affiliations:

Allemagne

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to stream Main, to step Curation: 002A74

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Base sequence homology between PR8 segment 4, the gene coding for the hemagglutinin, and the cRNAs of other influenza A prototype strains was determined. One hundred percent base sequence homology was found between PR8 (HO) and FMl (Hl), and 80% homology between PR8 and swine influenza virus (HSW1), although there is no cross-inhibition of hemagglutination. This is in clear contrast to other antigenically unrelated strains, which exhibit a base sequence homology between 20 and 40% with regard to segment 4. Fowl plague virus (FPV) and the Dutch strain, and equine 2 virus and the Hong Kong strain, which have antigenically related hemagglutinins, exhibit a base sequence homology of 100 and 80%, respectively. The available data suggest that swine, PR8, and FMl comprise one “subtype” genetically and are not derived by recombination, but differ by a number of point mutations.</div>
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Correlation between base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses

Correlation between base sequence homology of RNA segment 4 and antigenicity of the hemagglutinin of influenza viruses

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri